Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CASP7 | P55210 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405155 | 0.85 | KDM4E (0.58) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL855371 | 0.82 | ALDH1A1 (0.63) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL999012 | 0.79 | KDM4E (0.63) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL2965583 | 0.78 | AKR1C3 (0.53) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL9039800 | 0.78 | KDM4E (0.68) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL12640833 | 0.78 | KDM4E (0.53) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL2950898 | 0.78 | CYP3A4 (0.57) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL10932482 | 0.78 | KDM4E (0.68) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL2954701 | 0.78 | CASP7 (0.48) | KDM4ETDP1ALDH1A1MAPTKMT2A | |
| SCHEMBL10316128 | 0.78 | KDM4E (0.53) | KDM4ETDP1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160175-A1 | 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer | MARTIN CHRISTINE | 2011-06-30 | — | — | US | disclosed |
| WO-2008056189-A1 | 18, 21-DIDESOXYMACBECIN DERIVATIVES FOR THE TREATMENT OF CANCER | BIOTICA TECHNOLOGY LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160175-A1 | 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer | BCL3, CD22, MEN1 | KDM4E 2473/4885TDP1 3541/4885ALDH1A1 2496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.