CASP7 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL45609	0.57	6/20
Esculin (SCHEMBL2893)	1.00	5/20
Esculin (SCHEMBL2894)	1.00	5/20
SCHEMBL6627	0.49	5/20
SCHEMBL37694	0.47	5/20
Umbelliferone (SCHEMBL22018)	1.00	4/20
Esculetin (SCHEMBL24641)	1.00	4/20
SCHEMBL37677	1.00	4/20
Fisetin (SCHEMBL39454)	1.00	4/20
Flavonol (SCHEMBL20246)	0.71	4/20
SCHEMBL61603	0.55	4/20
SCHEMBL42876	0.55	4/20
SCHEMBL57038	0.53	4/20
SCHEMBL54876	0.44	4/20
Reserpine (SCHEMBL2589)	1.00	3/20
Topotecan (SCHEMBL3836)	1.00	3/20
Topotecan (SCHEMBL7247)	1.00	3/20
Topotecan (SCHEMBL7248)	1.00	3/20
Riboflavin (SCHEMBL7706)	1.00	3/20
Riboflavin (SCHEMBL7707)	1.00	3/20

Clinical trials — most relevant to CASP7 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Chemotherapy Drug Sensitivity Microculture (MiCK) Assay for Apoptosis	PHASE2/PHASE3	COMPLETED
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation	PHASE2	COMPLETED
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
18F-CP18 Imaging Studies for Cancer Treatment With Birinapant	PHASE2	WITHDRAWN
Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
A Clinical Trial of TQB3909 Tablets in Subjects With Advanced Malignant Tumors	PHASE1	UNKNOWN
Interleukin-7 in Treating Patients With Refractory Solid Tumors	PHASE1	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan	nan	UNKNOWN
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.	nan	UNKNOWN
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Microculture Kinetic (MiCK) Apoptosis Test Results With Drug Treatment Results in Cancer Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CASP7 binder may also engage these)

Protein	Name	Similarity
P55214	—	1.000	P55214 →
P97864	—	0.999	P97864 →
F1NV61	—	0.986	F1NV61 →
Q5IS54	—	0.983	Q5IS54 →
CASP3	Caspase-3	0.981	landscape →
Q08DY9	—	0.979	Q08DY9 →
P55213	—	0.979	P55213 →
Q5IS99	—	0.976	Q5IS99 →
P70677	—	0.975	P70677 →
Q8MKI5	—	0.975	Q8MKI5 →
Q8MJU1	—	0.973	Q8MJU1 →
Q95ND5	—	0.973	Q95ND5 →
Q2PFV2	—	0.971	Q2PFV2 →
Q60431	—	0.969	Q60431 →
Q8MJC3	—	0.955	Q8MJC3 →
CASP6	Caspase-6	0.951	landscape →
O08738	—	0.945	O08738 →
O35397	—	0.940	O35397 →
Q3T0P5	—	0.931	Q3T0P5 →
Q9MZV7	—	0.927	Q9MZV7 →
Q9MZV6	—	0.927	Q9MZV6 →
A0A1D5PPP7	—	0.925	A0A1D5PPP7 →
Q9TV13	—	0.923	Q9TV13 →
Q9N2I1	—	0.921	Q9N2I1 →
CASP1	Caspase-1	0.921	landscape →
O75601	—	0.921	O75601 →
P27117	—	0.918	P27117 →
P27119	—	0.917	P27119 →
Q5E9C1	—	0.915	Q5E9C1 →
P27118	—	0.914	P27118 →