Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FER | P16591 | 4/20 | 0.52 |
| ▸ | SYK | P43405 | 13/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GALR2 | O43603 | 1/20 | 0.44 |
| ▸ | GALR1 | P47211 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987645 | 0.86 | FER (0.57) | FERSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL12640800 | 0.80 | TP53 (0.55) | SYKKCNH2MAPK1AURKBNPC1 | |
| SCHEMBL16976717 | 0.77 | SYK (0.51) | FERSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL23397913 | 0.73 | SYK (0.53) | FERSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL1986849 | 0.73 | SYK (0.53) | FERSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL12640878 | 0.73 | SYK (0.46) | FERSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL12640925 | 0.71 | CISD2 (0.46) | FERSYKMAPK1AURKBNPC1 | |
| SCHEMBL1989300 | 0.71 | SYK (0.76) | FERSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL22475336 | 0.71 | FER (0.55) | FERSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL1988785 | 0.71 | SYK (0.49) | FERSYKKCNH2MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079051-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-30 | — | — | WO | disclosed |