Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12640925 | 0.81 | CISD2 (0.46) | TP53MAPTCISD2LMNATSHR | |
| SCHEMBL12640993 | 0.80 | FER (0.52) | MAPK1NPC1RAB9AAURKBSYK | |
| SCHEMBL1989865 | 0.78 | NFKB1 (0.51) | TP53MAPTCISD2LMNATSHR | |
| SCHEMBL1986001 | 0.78 | NFKB1 (0.51) | TP53MAPTCISD2LMNATSHR | |
| SCHEMBL1988610 | 0.76 | LMNA (0.48) | TP53MAPTCISD2LMNATSHR | |
| SCHEMBL1986008 | 0.74 | KMT2A (0.46) | TP53MAPTCISD2LMNATSHR | |
| SCHEMBL1986224 | 0.73 | FER (0.46) | TP53MAPTCISD2LMNATSHR | |
| SCHEMBL16743301 | 0.72 | KDR (0.50) | TP53MAPTMAPK1EGFRROCK1 | |
| SCHEMBL15887222 | 0.71 | NPC1 (0.50) | TP53MAPTLMNATSHRNPC1 | |
| SCHEMBL10254010 | 0.71 | NFKB1 (0.49) | TP53MAPTLMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079051-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-30 | — | — | WO | disclosed |