Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.67 |
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14116099 | 0.88 | SIGMAR1 (0.65) | SIGMAR1LTA4HPOLBL3MBTL1 | |
| SCHEMBL12642482 | 0.85 | SIGMAR1 (0.72) | SIGMAR1 | |
| SCHEMBL14116235 | 0.84 | SIGMAR1 (0.74) | SIGMAR1LTA4H | |
| SCHEMBL14116237 | 0.83 | SIGMAR1 (0.69) | SIGMAR1L3MBTL1 | |
| SCHEMBL14100732 | 0.83 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL14100464 | 0.80 | SIGMAR1 (0.64) | SIGMAR1 | |
| SCHEMBL14115981 | 0.80 | SIGMAR1 (0.67) | SIGMAR1LTA4H | |
| SCHEMBL14100581 | 0.80 | SIGMAR1 (0.60) | SIGMAR1POLB | |
| SCHEMBL15745866 | 0.79 | MEN1 (0.60) | SIGMAR1 | |
| SCHEMBL14100583 | 0.79 | SIGMAR1 (0.63) | SIGMAR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336125-A1 | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | Janssen Pharmaceutica N.V. (BE) | 2011-06-22 | — | — | EP | disclosed |
| WO-2009126806-A2 | THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-15 | — | — | WO | disclosed |