Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.74 |
| ▸ | LTA4H | P09960 | 3/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12642482 | 0.87 | SIGMAR1 (0.72) | SIGMAR1ACHEBACE1 | |
| SCHEMBL3075354 | 0.87 | SIGMAR1 (0.81) | SIGMAR1 | |
| SCHEMBL14116237 | 0.85 | SIGMAR1 (0.69) | SIGMAR1ACHEBACE1 | |
| SCHEMBL14115981 | 0.84 | SIGMAR1 (0.67) | SIGMAR1LTA4HACHEBACE1KCNH2 | |
| SCHEMBL12642613 | 0.84 | SIGMAR1 (0.67) | SIGMAR1LTA4H | |
| SCHEMBL14101123 | 0.83 | SIGMAR1 (0.70) | SIGMAR1ACHEBACE1 | |
| SCHEMBL14116099 | 0.82 | SIGMAR1 (0.65) | SIGMAR1LTA4HKCNH2 | |
| SCHEMBL14100464 | 0.82 | SIGMAR1 (0.64) | SIGMAR1ACHEBACE1 | |
| SCHEMBL4034602 | 0.81 | SIGMAR1 (0.83) | SIGMAR1 | |
| SCHEMBL14100583 | 0.81 | SIGMAR1 (0.63) | SIGMAR1ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |