Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855546 | 0.89 | HRH3 (0.74) | HRH3GAASMN1; SMN2OPRK1ACHE | |
| SCHEMBL28641327 | 0.88 | HRH3 (0.61) | HRH3GAASMN1; SMN2OPRK1CARM1 | |
| SCHEMBL12642720 | 0.86 | HRH3 (0.53) | HRH3GAASMN1; SMN2 | |
| SCHEMBL12642606 | 0.84 | LTA4H (0.61) | HRH3OPRK1 | |
| SCHEMBL5203366 | 0.82 | HRH3 (0.69) | HRH3GAASMN1; SMN2OPRK1 | |
| SCHEMBL28633821 | 0.82 | HRH3 (0.57) | HRH3GAASMN1; SMN2OPRK1CARM1 | |
| SCHEMBL13463052 | 0.81 | HRH3 (0.70) | HRH3GAASMN1; SMN2OPRK1ACHE | |
| SCHEMBL3022526 | 0.81 | HRH3 (0.71) | HRH3GAASMN1; SMN2OPRK1ACHE | |
| SCHEMBL8393625 | 0.81 | HRH3 (0.71) | HRH3GAASMN1; SMN2OPRK1ACHE | |
| SCHEMBL10607825 | 0.80 | HRH3 (0.62) | HRH3GAASMN1; SMN2OPRK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336125-A1 | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | Janssen Pharmaceutica N.V. (BE) | 2011-06-22 | — | — | EP | disclosed |