Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 10/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | HTT | P42858 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12644453 | 0.88 | BRD4 (0.41) | BRD4MEN1KMT2AMAPTHTT | |
| SCHEMBL19387713 | 0.86 | MAPT (0.37) | MEN1KMT2AMAPTHTTNPC1 | |
| SCHEMBL12644242 | 0.84 | MEN1 (0.42) | BRD4MEN1KMT2AMAPTHTT | |
| SCHEMBL19099695 | 0.78 | MEN1 (0.40) | BRD4MEN1KMT2AMAPTHTT | |
| SCHEMBL13551972 | 0.77 | ALDH1A1 (0.46) | BRD4MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL12644388 | 0.76 | MAPT (0.39) | MEN1KMT2AMAPTHTTNPC1 | |
| SCHEMBL13551999 | 0.76 | HGFAC (0.46) | BRD4MEN1KMT2AMAPTHTT | |
| SCHEMBL19387677 | 0.74 | HTR2A (0.37) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL12644514 | 0.72 | MAPT (0.42) | BRD4MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL13552104 | 0.71 | HGFAC (0.60) | MEN1KMT2AMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075210-A2 | SMALL MOLECULES THAT COVALENTLY MODIFY TRANSTHYRETIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | WO | disclosed |