Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12644453 | 0.86 | BRD4 (0.41) | MAPTLMNAALDH1A1GAAHTT | |
| SCHEMBL19387713 | 0.86 | MAPT (0.37) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL19387677 | 0.85 | HTR2A (0.37) | MAPTLMNAALDH1A1GAAHTT | |
| SCHEMBL13551997 | 0.78 | MAPT (0.46) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL12644392 | 0.76 | BRD4 (0.41) | MAPTLMNAALDH1A1GAAHTT | |
| SCHEMBL19387723 | 0.76 | MAOB (0.35) | MAPTLMNAALDH1A1GAAHTT | |
| SCHEMBL13551974 | 0.74 | ALDH1A1 (0.47) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL9807385 | 0.73 | ALDH1A1 (0.53) | MAPTLMNAALDH1A1HTTMEN1 | |
| SCHEMBL12644242 | 0.73 | MEN1 (0.42) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL12644251 | 0.71 | MAOB (0.59) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075210-A2 | SMALL MOLECULES THAT COVALENTLY MODIFY TRANSTHYRETIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | WO | disclosed |