⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16401454 | 0.80 | NPC1 (0.39) | — | |
| SCHEMBL10245233 | 0.78 | — | — | |
| SCHEMBL7774536 | 0.78 | KMT2A (0.41) | — | |
| SCHEMBL29071044 | 0.77 | — | — | |
| SCHEMBL15806526 | 0.77 | L3MBTL1 (0.51) | — | |
| SCHEMBL16447016 | 0.77 | EGLN1 (0.38) | — | |
| SCHEMBL15432818 | 0.75 | L3MBTL1 (0.36) | — | |
| SCHEMBL28954014 | 0.75 | L3MBTL1 (0.36) | — | |
| SCHEMBL16447140 | 0.75 | L3MBTL1 (0.36) | — | |
| SCHEMBL28020167 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066662-B1 | SERINE HYDROLASE INHIBITORS | KYORIN SEIYAKU KK (JP) | 2012-12-05 | — | — | EP | claimed |
| US-7879846-B2 | e.g. 2-(2-Imidazol-1-yl-pyridin-3-yl)-5-methyl-4H-benz[d][1,3]oxazin-4-one ; neutrophil elastase inhibitor; antiinflammatory agent, respiratory system disorders | Kyorin Pharmaceutical Co.., Ltd. (JP) | 2011-02-01 | — | — | US | claimed |
| EP-2066662-A2 | SERINE HYDROLASE INHIBITORS | Activx Biosciences, Inc. (US) | 2009-06-10 | — | — | EP | claimed |
| US-20080161290-A1 | Serine hydrolase inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-07-03 | — | — | US | claimed |
| WO-2008036379-A2 | SERINE HYDROLASE INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2008-03-27 | — | — | WO | claimed |
| EP-2066662-B1 | SERINE HYDROLASE INHIBITORS | KYORIN SEIYAKU KK (JP) | 2012-12-05 | — | — | EP | disclosed |
| US-7879846-B2 | e.g. 2-(2-Imidazol-1-yl-pyridin-3-yl)-5-methyl-4H-benz[d][1,3]oxazin-4-one ; neutrophil elastase inhibitor; antiinflammatory agent, respiratory system disorders | Kyorin Pharmaceutical Co.., Ltd. (JP) | 2011-02-01 | — | — | US | disclosed |
| EP-2066662-A2 | SERINE HYDROLASE INHIBITORS | Activx Biosciences, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| US-20080161290-A1 | Serine hydrolase inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| WO-2008036379-A2 | SERINE HYDROLASE INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2008-03-27 | — | — | WO | disclosed |