Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL31438317 | 0.98 | TP53 (0.55) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL338255 | 0.98 | TP53 (0.55) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL2801896 | 0.95 | TP53 (0.52) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL28298880 | 0.95 | TP53 (0.52) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Lactic Acid SCHEMBL1132260 | 0.86 | TP53 (0.42) | TP53MAPT | |
| Trolamine SCHEMBL1054050 | 0.83 | SLC7A5 (0.41) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL5874119 | 0.83 | MAPT (0.37) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL1054048 | 0.83 | SLC7A5 (0.41) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL28326171 | 0.81 | MAPT (0.35) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Lactic Acid SCHEMBL1131790 | 0.81 | MAPT (0.57) | TP53MAPTKDM4EOR51E2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250145882-A1 | DUAL-POLYMER HYDRAULIC FRACTURING FLUID AND METHOD FOR PUMPING THE SAME INTO SUBTERRANEAN FORMATIONS | SAUDI ARABIAN OIL COMPANY (SA) | 2025-05-08 | — | — | US | claimed |
| US-12221580-B1 | Dual-polymer hydraulic fracturing fluid and method for pumping the same into subterranean formations | SAUDI ARABIAN OIL COMPANY (SA) | 2025-02-11 | — | — | US | claimed |
| CN-115746819-B | Intelligent temperature control crosslinking integrated suspension emulsion system suitable for salt-tolerant biological glue and preparation method thereof | 重庆力宏精细化工有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-115746819-A | Intelligent temperature control crosslinking integrated suspended emulsion system suitable for salt-tolerant biogum and preparation method thereof | 重庆力宏精细化工有限公司 | 2023-03-07 | — | — | CN | claimed |
| CN-109863221-B | Polymer blends for stimulation of oil and gas wells | 罗地亚经营管理公司 | 2021-12-24 | — | — | CN | claimed |
| EP-2494001-A1 | WELL TREATMENT FLUIDS CONTAINING A VISCOELASTIC SURFACTANT AND A CROSS-LINKING AGENT COMPRISING A WATER-SOLUBLE TRANSITION METAL COMPLEX | Halliburton Energy Services, Inc. (US) | 2012-09-05 | — | — | EP | claimed |
| US-20110105369-A1 | WELL TREATMENT FLUIDS CONTAINING A VISCOELASTIC SURFACTANT AND A CROSS-LINKING AGENT COMPRISING A WATER-SOLUBLE TRANSITION METAL COMPLEX | HALLIBURTON ENERGY SERVICES, INC. | 2011-05-05 | — | — | US | claimed |
| WO-2011051683-A1 | WELL TREATMENT FLUIDS CONTAINING A VISCOELASTIC SURFACTANT AND A CROSS-LINKING AGENT COMPRISING A WATER-SOLUBLE TRANSITION METAL COMPLEX | HALLIBURTON ENERGY SERVICES, INC. (US) | 2011-05-05 | — | — | WO | claimed |
| EP-0302544-B1 | HIGH TEMPERATURE GUAR-BASED FRACTURING FLUID | PUMPTECH N.V. (BE) | 1992-06-03 | — | — | EP | claimed |
| EP-0302544-A2 | High temperature guar-based fracturing fluid | PUMPTECH N.V. (BE) | 1989-02-08 | — | — | EP | claimed |
| US-4801389-A | ZIRCONIUM OR HAFNIUM CROSSLINKING AGENT, BICARBONATE SALT | DOWELL SCHLUMBERGER INCORPORATED (US) | 1989-01-31 | — | — | US | claimed |
| US-4702848-A | Control of crosslinking reaction rate using organozirconate chelate crosslinking agent and aldehyde retarding agent | DOWELL SCHLUMBERGER INCORPORATED (US) | 1987-10-27 | — | — | US | claimed |
| CN-115746819-B | Intelligent temperature control crosslinking integrated suspension emulsion system suitable for salt-tolerant biological glue and preparation method thereof | 重庆力宏精细化工有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-115746819-A | Intelligent temperature control crosslinking integrated suspended emulsion system suitable for salt-tolerant biogum and preparation method thereof | 重庆力宏精细化工有限公司 | 2023-03-07 | — | — | CN | disclosed |
| US-10023789-B2 | Enhancing complex fracture networks in subterranean formations | HALLIBURTON ENERGY SERVICES, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| CN-103797019-B | Method for controlling depolymerization of polymer compositions | 罗地亚管理公司 | 2018-04-03 | — | — | CN | disclosed |
| EP-0302544-B1 | HIGH TEMPERATURE GUAR-BASED FRACTURING FLUID | PUMPTECH N.V. (BE) | 1992-06-03 | — | — | EP | disclosed |
| EP-0302544-A2 | High temperature guar-based fracturing fluid | PUMPTECH N.V. (BE) | 1989-02-08 | — | — | EP | disclosed |
| US-4801389-A | ZIRCONIUM OR HAFNIUM CROSSLINKING AGENT, BICARBONATE SALT | DOWELL SCHLUMBERGER INCORPORATED (US) | 1989-01-31 | — | — | US | disclosed |
| US-4702848-A | Control of crosslinking reaction rate using organozirconate chelate crosslinking agent and aldehyde retarding agent | DOWELL SCHLUMBERGER INCORPORATED (US) | 1987-10-27 | — | — | US | disclosed |