Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL28298880 | 1.00 | TP53 (0.52) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL338255 | 0.98 | TP53 (0.55) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL31438317 | 0.98 | TP53 (0.55) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL1264568 | 0.95 | TP53 (0.52) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Lactic Acid SCHEMBL1132260 | 0.86 | TP53 (0.42) | TP53MAPT | |
| Trolamine SCHEMBL1054050 | 0.83 | SLC7A5 (0.41) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL5874119 | 0.83 | MAPT (0.37) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL1054048 | 0.83 | SLC7A5 (0.41) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL740171 | 0.82 | MAPT (0.40) | MAPTKDM4EALOX15SMN1; SMN2LMNA | |
| Trolamine SCHEMBL27571328 | 0.82 | MAPT (0.40) | MAPTKDM4EALOX15SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220348820-A1 | CROSSLINKED PROPPANT-GEL MATRIX | HEXION INC. | 2022-11-03 | — | — | US | claimed |
| US-11447689-B2 | Crosslinked proppant-gel matrix | HEXION INC. (US) | 2022-09-20 | — | — | US | claimed |
| US-20210095186-A1 | CROSSLINKED PROPPANT-GEL MATRIX | HEXION INC. | 2021-04-01 | — | — | US | claimed |
| US-10883041-B2 | Crosslinked proppant-gel matrix | HEXION INC. (US) | 2021-01-05 | — | — | US | claimed |
| US-20180346799-A1 | CROSSLINKED PROPPANT-GEL MATRIX | ROYAL BANK OF CANADA, AS ADMINISTRATIVE AGENT (CA) | 2018-12-06 | — | — | US | claimed |
| CN-118048142-A | Preparation method of anhydrous organic titanium cross-linking agent concentrated solution and cross-linked integrated suspension fracturing fluid | 重庆科技大学 | 2024-05-17 | — | — | CN | disclosed |
| US-11746281-B2 | Crosslinked proppant-gel matrix | HEXION INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-20220348820-A1 | CROSSLINKED PROPPANT-GEL MATRIX | HEXION INC. | 2022-11-03 | — | — | US | disclosed |
| US-11447689-B2 | Crosslinked proppant-gel matrix | HEXION INC. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20210095186-A1 | CROSSLINKED PROPPANT-GEL MATRIX | HEXION INC. | 2021-04-01 | — | — | US | disclosed |
| US-10883041-B2 | Crosslinked proppant-gel matrix | HEXION INC. (US) | 2021-01-05 | — | — | US | disclosed |
| US-20180346799-A1 | CROSSLINKED PROPPANT-GEL MATRIX | ROYAL BANK OF CANADA, AS ADMINISTRATIVE AGENT (CA) | 2018-12-06 | — | — | US | disclosed |
| US-7732382-B2 | Cross-linking composition and method of use | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-06-08 | — | — | US | disclosed |
| WO-2007095367-A2 | CROSS-LINKING COMPOSITION AND METHOD OF USE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20070187098-A1 | Permeable zone and leak plugging using cross-linking composition comprising delay agent | E. I. DU PONT DE NEMOURS AND COMPANY | 2007-08-16 | — | — | US | disclosed |
| US-20070187102-A1 | Hydraulic fracturing methods using cross-linking composition comprising delay agent | E. I. DU PONT DE NEMOURS AND COMPANY | 2007-08-16 | — | — | US | disclosed |
| US-20070191233-A1 | Cross-linking composition and method of use | DORF KETAL SPECIALITY CATALYSTS, LLC | 2007-08-16 | — | — | US | disclosed |