Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL31438317 | 1.00 | TP53 (0.55) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL1264568 | 0.98 | TP53 (0.52) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL28298880 | 0.98 | TP53 (0.52) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL2801896 | 0.98 | TP53 (0.52) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Lactic Acid SCHEMBL1132260 | 0.88 | TP53 (0.42) | TP53MAPT | |
| Trolamine SCHEMBL1054050 | 0.85 | SLC7A5 (0.41) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL5874119 | 0.85 | MAPT (0.37) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL1054048 | 0.85 | SLC7A5 (0.41) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL28326171 | 0.83 | MAPT (0.35) | TP53MAPTKDM4EALOX15SMN1; SMN2 | |
| Lactic Acid SCHEMBL1131790 | 0.83 | MAPT (0.57) | TP53MAPTKDM4EOR51E2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 308 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12350365-B2 | Products and methods for reducing malodor from the pudendum | WELLS FARGO BANK, N.A. | 2025-07-08 | — | — | US | claimed |
| US-20250195341-A1 | Personal Care Compositions Incorporating Natural Benefit Agents And Methods For The Same | COLGATE-PALMOLIVE COMPANY (US) | 2025-06-19 | — | — | US | claimed |
| EP-3836889-B1 | SOLID CLEANSING COMPOSTIONS AND METHODS FOR THE SAME | COLGATE PALMOLIVE CO (US) | 2025-05-14 | — | — | EP | claimed |
| EP-4355286-A1 | SOLID PERSONAL CARE COMPOSITIONS INCORPORATING NATURAL BENEFIT AGENTS SUCH AS FLAXSEED OIL AND METHODS FOR THE SAME | Colgate-Palmolive Company (US) | 2024-04-24 | — | — | EP | claimed |
| EP-3824883-B1 | NOVEL COMPOSITION FOR PLASTER BASE MATERIAL IN TAPE PREPARATION | MEDRX CO LTD (JP) | 2023-08-02 | — | — | EP | claimed |
| CN-115716922-A | Lignin demethylation method based on low-cost proton type ionic liquid | 北京理工大学 | 2023-02-28 | — | — | CN | claimed |
| US-20230042771-A1 | Personal Care Compositions Incorporating Natural Benefit Agents and Methods for the Same | COLGATE-PALMOLIVE COMPANY (US) | 2023-02-09 | — | — | US | claimed |
| WO-2023004100-A1 | SOLID PERSONAL CARE COMPOSITIONS INCORPORATING NATURAL BENEFIT AGENTS SUCH AS FLAXSEED OIL AND METHODS FOR THE SAME | COLGATE-PALMOLIVE COMPANY (US) | 2023-01-26 | — | — | WO | claimed |
| EP-2865376-B2 | ADHESIVE PREPARATION COMPOSITION OBTAINED BY BLENDING DRUG, ORGANIC SOLVENT, LIPOPHILIC OINTMENT BASE, AND POWDER | MEDRX CO LTD (JP) | 2022-05-11 | — | — | EP | claimed |
| CN-110862335-B | Preparation method of VEGFR2 selective inhibitor SU1498 | 安莱博医药(苏州)有限公司 | 2022-03-15 | — | — | CN | claimed |
| WO-2010136478-A9 | METHOD FOR IMPROVING THE MILDNESS OF CLEANSING COMPOSITIONS | PURAC BIOCHEM BV (NL) | 2012-02-02 | — | — | WO | claimed |
| CN-102299322-A | Ion hot preparation method for lithium iron phosphate positive electrode material | — | 2011-12-28 | — | — | CN | claimed |
| CN-102299325-A | Ionothermal process of manganese lithium phosphate anode material | — | 2011-12-28 | — | — | CN | claimed |
| WO-2010136478-A2 | METHOD FOR IMPROVING THE MILDNESS OF CLEANSING COMPOSITIONS | PURAC BIOCHEM BV (NL) | 2010-12-02 | — | — | WO | claimed |
| EP-2255776-A1 | Cleansing composition | PURAC Biochem BV (NL) | 2010-12-01 | — | — | EP | claimed |
| CN-101310703-A | Foamable alcoholic compositions | GOJO IND INC (US) | 2008-11-26 | — | — | CN | claimed |
| US-20020125012-A1 | Well treatment fluid compositions and methods for their use | BJ SERVICES COMPANY | 2002-09-12 | — | — | US | claimed |
| WO-2002055843-A1 | WELL TREATMENT FLUID COMPOSITIONS AND METHODS FOR THEIR USE | BJ SERVICES COMPANY (US) | 2002-07-18 | — | — | WO | claimed |
| US-5712232-A | ANIONIC SURFACTANT AND A SALT | KAO CORPORATION (JP) | 1998-01-27 | — | — | US | claimed |
| US-5233065-A | Partial chelation with salts of alpha hydroxy carboxylic acids | ZIRCONIUM TECHNOLOGY CORPORATION (US) | 1993-08-03 | — | — | US | claimed |