SCHEMBL12646166

SCHEMBL12646166

CCC(CC)c1ccc(CN2CCOCC2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 5/20 0.61
SMN1; SMN2 Q16637 3/20 0.57
NOS3 P29474 1/20 0.50
NOS1 P29475 1/20 0.50
NOS2 P35228 1/20 0.50
MAPT P10636 3/20 0.49
ALDH1A1 P00352 2/20 0.49
LMNA P02545 1/20 0.49
KCNJ1 P48048 1/20 0.49
HPGD P15428 2/20 0.46
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.46
TP53 P04637 1/20 0.46
TSHR P16473 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 1/20 0.46
HIF1A Q16665 2/20 0.46
EPAS1 Q99814 2/20 0.46
HTT P42858 1/20 0.46
GAA P10253 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10077424 0.85 HRH3 (0.59) HRH3SMN1; SMN2NOS3NOS1NOS2
SCHEMBL18538130 0.84 HRH3 (0.57) HRH3SMN1; SMN2NOS3NOS1NOS2
SCHEMBL18538137 0.84 HRH3 (0.57) HRH3SMN1; SMN2NOS3NOS1NOS2
SCHEMBL4547887 0.83 HRH3 (0.65) HRH3SMN1; SMN2NOS3NOS1NOS2
SCHEMBL16604253 0.83 HRH3 (0.46) HRH3SMN1; SMN2MAPTALDH1A1LMNA
SCHEMBL15467001 0.82 HRH3 (0.87) HRH3SMN1; SMN2NOS3NOS1NOS2
SCHEMBL13531007 0.81 NCF1 (0.57) HRH3SMN1; SMN2NOS1MAPTALDH1A1
SCHEMBL16604254 0.81 HRH3 (0.54) HRH3SMN1; SMN2NOS3NOS1NOS2
SCHEMBL19441582 0.81 HRH3 (0.62) HRH3SMN1; SMN2NOS3NOS1NOS2
SCHEMBL19441606 0.81 HRH3 (0.62) HRH3SMN1; SMN2NOS3NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7956052-B2 Modulators of ATP-binding cassette transporters VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-06-07 US disclosed