Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18538130 | 0.98 | HRH3 (0.57) | HRH3ALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL18538137 | 0.98 | HRH3 (0.57) | HRH3ALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL24170702 | 0.88 | HRH3 (0.56) | HRH3ALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL12646166 | 0.85 | HRH3 (0.61) | HRH3ALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL23746339 | 0.85 | HRH3 (0.53) | HRH3ALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL4547887 | 0.85 | HRH3 (0.65) | HRH3ALDH1A1SMN1; SMN2HTTNOS3 | |
| SCHEMBL10178474 | 0.85 | HRH3 (0.59) | HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL19441582 | 0.83 | HRH3 (0.62) | HRH3ALDH1A1SMN1; SMN2HTTNOS3 | |
| SCHEMBL10178419 | 0.83 | HRH3 (0.62) | HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL19441606 | 0.83 | HRH3 (0.62) | HRH3ALDH1A1SMN1; SMN2HTTNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372971-B2 | Heterocyclic compounds and methods of use | TARGEGEN, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8361700-B2 | Lithographic printing plate precursor and method of preparing lithographic printing plate | FUJIFILM CORPORATION (JP) | 2013-01-29 | — | — | US | disclosed |
| US-20120264747-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | ZHU BING-YAN (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120220584-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | TARGEGEN, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20080241740-A1 | Support with photosensitive layer; reduce contact angle of water drops | FUJIFILM CORPORATION (JP) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220584-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AADAC, NISCH, PAICS | HRH3 489/4885ALDH1A1 1642/4885SMN1; SMN2 3696/4885 |
| US-20120264747-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | HRH3 393/4885ALDH1A1 2375/4885SMN1; SMN2 1522/4885 |
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HRH3 3227/4885ALDH1A1 1335/4885SMN1; SMN2 2153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.