Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20289179 | 0.90 | TAS1R3 (0.47) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL12844553 | 0.84 | PPARG (0.55) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL13052228 | 0.84 | ALDH1A1 (0.48) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL20032378 | 0.84 | MAPT (0.46) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL22504117 | 0.83 | TNF (0.46) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL24015482 | 0.82 | CYP3A4 (0.50) | MEN1KMT2AMAPTLMNATAS1R3 | |
| SCHEMBL15157517 | 0.82 | MEN1 (0.44) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL20032313 | 0.82 | CSNK2A1 (0.54) | MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2670001 | 0.79 | HDAC4 (0.47) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL2632704 | 0.78 | AHR (0.44) | LMNAALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956052-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-07 | — | — | US | disclosed |