Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878912 | 0.92 | CSF1R (0.52) | CSF1RKITKDRADORA2AMAP2K1 | |
| SCHEMBL1267898 | 0.91 | ADORA2A (0.55) | CSF1RKITKDRADORA2AMAP2K1 | |
| SCHEMBL878837 | 0.89 | CSF1R (0.68) | CSF1RKITKDRADORA2ACDC7 | |
| SCHEMBL12927332 | 0.88 | CSF1R (0.50) | CSF1RKITKDRADORA2AMAP2K1 | |
| SCHEMBL15987202 | 0.85 | KIT (0.55) | CSF1RKITKDRMAP2K1PKM | |
| SCHEMBL1268072 | 0.85 | CLK1 (0.50) | CSF1RKITKDRADORA2APKM | |
| SCHEMBL4531204 | 0.83 | CDC7 (0.48) | CSF1RKITKDRADORA2AMAP2K1 | |
| SCHEMBL878889 | 0.81 | HDAC3 (0.44) | CSF1RKITKDRADORA2AMAP2K1 | |
| SCHEMBL858185 | 0.80 | HCAR3 (0.54) | CSF1RKITKDRADORA2AMAP2K1 | |
| SCHEMBL12646996 | 0.80 | CSF1R (0.78) | CSF1RKITKDRCDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947708-B2 | Compounds modulating C-kit activity | PLEXXIKON, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-7893075-B2 | Compounds modulating c-fms and/or c-kit activity and uses therefor | PLEXXIKON, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090105297-A1 | Compounds Modulating C-Kit Activity | PLEXXIKON INC | 2009-04-23 | — | — | US | disclosed |
| US-20090076046-A1 | Compounds modulating c-fms and/or c-kit activity and uses therefor | PLEXXIKON INC | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076046-A1 | Compounds modulating c-fms and/or c-kit activity and uses therefor | KIT, FLT3, FLT1 | CSF1R 4/4885KIT 1/4885KDR 21/4885 |
| US-20090105297-A1 | Compounds Modulating C-Kit Activity | KIT, CDC7, CDK7 | CSF1R 363/4885KIT 1/4885KDR 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.