Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | PRNP | P04156 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | NR0B1 | P51843 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brefeldin A SCHEMBL4967925 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL30460472 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL17167480 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL30460466 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL29268 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL13073124 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL4967944 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL4345242 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL8264765 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP | |
| Brefeldin A SCHEMBL26040278 | 1.00 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10940188-B2 | Compounds and methods for treatment and prevention of Flavivirus infection | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| US-20200164051-A1 | COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION | ACER THERAPEUTICS INC. | 2020-05-28 | — | — | US | disclosed |
| US-20180015153-A1 | COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2018-01-18 | — | — | US | disclosed |
| US-20180015153-A1 | COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2018-01-18 | — | — | US | disclosed |
| US-9034798-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | CAPROTEC BIOANALYTICS GMBH (DE) | 2015-05-19 | — | — | US | disclosed |
| US-8569481-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110118136-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | KOESTER HUBERT | 2011-05-19 | — | — | US | disclosed |
| US-20100248264-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | HK PHARMACEUTICALS, INC. | 2010-09-30 | — | — | US | disclosed |
| EP-1485707-B1 | CAPTURE COMPOUNDS, COLLECTIONS THEREOF AND METHODS FOR ANALYZING THE PROTEOME AND COMPLEX COMPOSITIONS | CAPROTEC BIOANALYTICS GMBH (DE) | 2009-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200164051-A1 | COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION | CDK2, CDKN1A, PSENEN | NPC1 1989/4885RAB9A 1540/4885LMNA 97/4885 |
| US-10940188-B2 | Compounds and methods for treatment and prevention of Flavivirus infection | CDK2, CDKN1A, PSENEN | NPC1 1989/4885RAB9A 1540/4885LMNA 97/4885 |
| US-20110118136-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PTMS, QPCTL, SRMS | NPC1 4421/4885RAB9A 2541/4885LMNA 2156/4885 |
| US-20180015153-A1 | COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION | CDK2, CDKN1A, PSENEN | NPC1 1989/4885RAB9A 1540/4885LMNA 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.