Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | POLQ | O75417 | 2/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18682072 | 0.81 | ESR1 (0.40) | IDO1CYP3A4CYP2D6HTR2ASLC6A4 | |
| SCHEMBL19725441 | 0.81 | DAO (0.45) | IDO1KIF11TSHRMAPK1HTR2A | |
| SCHEMBL10026823 | 0.79 | PDE2A (0.40) | IDO1KIF11CYP3A4CYP2D6TSHR | |
| SCHEMBL13021064 | 0.79 | IDO1 (0.54) | IDO1KIF11CYP3A4CYP2D6TSHR | |
| SCHEMBL14275212 | 0.79 | CES2 (0.43) | IDO1KIF11CYP3A4CYP2D6TSHR | |
| SCHEMBL2600028 | 0.79 | IDO1 (0.54) | IDO1KIF11TSHRMAPK1SLC6A4 | |
| SCHEMBL13644756 | 0.79 | POLQ (0.46) | IDO1KIF11CYP3A4CYP2D6DAO | |
| SCHEMBL20150065 | 0.78 | KIF11 (0.40) | IDO1KIF11CYP3A4CYP2D6TSHR | |
| SCHEMBL13020820 | 0.78 | SLC6A4 (0.44) | IDO1TSHRHTR2ASLC6A4KCNH2 | |
| SCHEMBL16997378 | 0.78 | PDE2A (0.46) | IDO1CYP3A4TSHRMAPK1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |