Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 17/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | IL6 | P05231 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12652117 | 0.94 | TLR7 (0.49) | TLR7TLR8CYP3A4IL6 | |
| SCHEMBL12651796 | 0.93 | TLR7 (0.47) | TLR7TLR8CYP3A4CYP2D6IL6 | |
| SCHEMBL12651791 | 0.91 | TLR7 (0.48) | TLR7TLR8CYP3A4IL6 | |
| SCHEMBL1869091 | 0.87 | TLR7 (0.57) | TLR7IL6 | |
| SCHEMBL13274361 | 0.84 | TLR7 (0.66) | TLR7TLR8CYP3A4CYP2D6IL6 | |
| SCHEMBL12767475 | 0.84 | TLR7 (0.55) | TLR7IL6 | |
| SCHEMBL12766701 | 0.82 | TLR7 (0.53) | TLR7IL6 | |
| SCHEMBL12766970 | 0.79 | TLR7 (0.56) | TLR7IL6 | |
| SCHEMBL1869703 | 0.79 | TLR7 (0.60) | TLR7 | |
| SCHEMBL12652139 | 0.78 | TLR7 (0.43) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476270-B2 | Dihydropyrido[4,3-b]pyrazine-3-ones as modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2013-07-02 | — | — | US | claimed |
| US-8476270-B2 | Dihydropyrido[4,3-b]pyrazine-3-ones as modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| US-20110124627-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| WO-2011031965-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124627-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR6, TLR1 | TLR7 9/4885TLR8 7/4885CYP3A4 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.