Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 5/20 | 0.44 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.44 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.44 |
| ▸ | ATG7 | O95352 | 1/20 | 0.44 |
| ▸ | UBA7 | P41226 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18631615 | 0.90 | NAE1 (0.51) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1798415 | 0.84 | UBA6 (0.58) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1798413 | 0.84 | UBA6 (0.58) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL12566820 | 0.79 | NAE1 (0.44) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL17898105 | 0.77 | NAE1 (0.71) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL12566826 | 0.73 | NAE1 (0.71) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1796096 | 0.73 | UBA6 (0.60) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL12617332 | 0.73 | UBA6 (0.60) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1796094 | 0.73 | UBA6 (0.60) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL20008056 | 0.73 | NAE1 (0.48) | NAE1UBA3UBA6ATG7UBA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951810-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |