Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 17/20 | 0.48 |
| ▸ | UBA3 | Q8TBC4 | 16/20 | 0.48 |
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.42 |
| ▸ | ATG7 | O95352 | 1/20 | 0.42 |
| ▸ | UBA7 | P41226 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18630514 | 0.85 | NAE1 (0.58) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL21283410 | 0.78 | TMIGD3 (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21283358 | 0.77 | NAE1 (0.42) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL17898105 | 0.77 | NAE1 (0.71) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL23080250 | 0.76 | NAE1 (0.38) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL23080267 | 0.76 | NAE1 (0.39) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL23080204 | 0.75 | P2RX7 (0.41) | NAE1UBA3PDE4APDE4BPDE4C | |
| SCHEMBL18631615 | 0.75 | NAE1 (0.51) | NAE1UBA3UBA6SAE1ATG7 | |
| SCHEMBL18631311 | 0.74 | ADORA3 (0.41) | NAE1UBA3PDE4APDE4BPDE4C | |
| SCHEMBL21283380 | 0.73 | NAE1 (0.58) | NAE1UBA3UBA6SAE1ATG7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENNIUM PHARMACEUTICALS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | NAE1 257/4885UBA3 235/4885UBA6 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.