Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | ATG7 | O95352 | 8/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | NT5E | P21589 | 2/20 | 0.39 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.39 |
| ▸ | UBA7 | P41226 | 1/20 | 0.39 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.39 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18630444 | 0.85 | ATG7 (0.47) | BCHEATG7NT5EUBA6UBA7 | |
| SCHEMBL8619307 | 0.83 | SMN1; SMN2 (0.45) | BCHE | |
| SCHEMBL8619304 | 0.83 | SMN1; SMN2 (0.45) | BCHE | |
| SCHEMBL17889872 | 0.80 | ATG7 (0.58) | ATG7NT5E | |
| SCHEMBL1802553 | 0.80 | ATG7 (0.58) | ATG7NT5E | |
| SCHEMBL21637063 | 0.79 | ALDH1A1 (0.47) | BCHENT5E | |
| SCHEMBL1800042 | 0.79 | ATG7 (0.63) | ATG7RXFP1UBA6UBA7NAE1 | |
| SCHEMBL9697091 | 0.77 | TP53 (0.40) | BCHE | |
| SCHEMBL24021890 | 0.75 | SLC29A1 (0.42) | BCHE | |
| SCHEMBL18630609 | 0.73 | HSP90B1 (0.36) | ATG7RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951810-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |