Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12165535 | 0.86 | IRAK4 (0.45) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL7088362 | 0.76 | IRAK4 (0.72) | IRAK4IDO1TDO2RXFP1ALDH1A1 | |
| SCHEMBL543548 | 0.71 | TSHR (0.56) | IRAK4RXFP1ALDH1A1ACHEMRGPRX1 | |
| SCHEMBL20496425 | 0.69 | IRAK4 (0.58) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL20496480 | 0.69 | IRAK4 (0.58) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL4020950 | 0.69 | IRAK4 (0.42) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL4017686 | 0.69 | ALDH1A1 (0.50) | IRAK4IDO1TDO2ALDH1A1KDM4E | |
| SCHEMBL12165506 | 0.68 | TSHR (0.52) | ALDH1A1LMNA | |
| SCHEMBL27694472 | 0.67 | IRAK4 (0.64) | IRAK4IDO1TDO2ALDH1A1ACHE | |
| SCHEMBL16453483 | 0.67 | IRAK4 (0.68) | IRAK4IDO1TDO2RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011053697-A1 | 2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA | GENZYME CORPORATION (US) | 2011-05-05 | — | — | WO | disclosed |