Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 18/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654633 | 0.89 | FGFR4 (0.48) | FGFR4 | |
| SCHEMBL12654216 | 0.89 | FGFR4 (0.62) | FGFR4CNR2 | |
| SCHEMBL12654399 | 0.88 | FGFR4 (0.59) | FGFR4CYP2C9 | |
| SCHEMBL12653785 | 0.86 | FGFR4 (0.59) | FGFR4CNR2 | |
| SCHEMBL12654527 | 0.85 | FGFR4 (0.56) | FGFR4CYP1A2CYP2C9 | |
| SCHEMBL16775864 | 0.85 | FGFR4 (0.44) | FGFR4NPC1LMNACYP1A2CYP2C9 | |
| SCHEMBL12654401 | 0.85 | CREBBP (0.44) | FGFR4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12654638 | 0.84 | FGFR4 (0.45) | FGFR4 | |
| SCHEMBL12653810 | 0.82 | FGFR4 (0.52) | FGFR4LMNACYP1A2CNR2 | |
| SCHEMBL12654193 | 0.82 | HTR2C (0.50) | FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |