Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654193 | 0.90 | HTR2C (0.50) | CSNK1EFGFR4CYP11B2HTR2CHTR2A | |
| SCHEMBL12654186 | 0.89 | CYP11B2 (0.45) | FGFR4CYP11B2HTR2C | |
| SCHEMBL17655360 | 0.88 | CREBBP (0.44) | CREBBPFGFR4SMN1; SMN2GPR142CNR1 | |
| SCHEMBL12654400 | 0.88 | P2RX1 (0.46) | CREBBPFGFR4GPR142HTR2CHTR2A | |
| SCHEMBL12654187 | 0.87 | FGFR4 (0.42) | CREBBPFGFR4CYP11B2ALDH1A1CNR1 | |
| SCHEMBL12654633 | 0.87 | FGFR4 (0.48) | FGFR4CYP11B2 | |
| SCHEMBL12959055 | 0.87 | FGFR4 (0.42) | CREBBPFGFR4CYP11B2HTR2CHTR2A | |
| SCHEMBL12654188 | 0.86 | CNR1 (0.43) | FGFR4CYP11B2TRPV1CNR1 | |
| SCHEMBL1812175 | 0.85 | CNR1 (0.43) | CREBBPFGFR4SMN1; SMN2ALDH1A1GPR142 | |
| SCHEMBL12654530 | 0.85 | CA2 (0.44) | CREBBPFGFR4GPR142HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |