Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654191 | 0.89 | FGFR4 (0.62) | FGFR4 | |
| SCHEMBL12654640 | 0.88 | FGFR4 (0.48) | FGFR4CYP11B2NPY5RKMO | |
| SCHEMBL12654639 | 0.87 | FGFR4 (0.49) | FGFR4NPY5RKMO | |
| SCHEMBL12654401 | 0.87 | CREBBP (0.44) | FGFR4CYP11B2 | |
| SCHEMBL12654193 | 0.85 | HTR2C (0.50) | FGFR4CYP11B2 | |
| SCHEMBL12654187 | 0.84 | FGFR4 (0.42) | FGFR4CYP11B2PDE4B | |
| SCHEMBL12654188 | 0.84 | CNR1 (0.43) | FGFR4CYP11B2KMO | |
| SCHEMBL12654186 | 0.83 | CYP11B2 (0.45) | FGFR4CYP11B2 | |
| SCHEMBL12654638 | 0.83 | FGFR4 (0.45) | FGFR4 | |
| SCHEMBL12959055 | 0.82 | FGFR4 (0.42) | FGFR4CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |