Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 7/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12653811 | 0.88 | FGFR4 (0.43) | FGFR4CNR2GRM5 | |
| SCHEMBL12654649 | 0.87 | CNR2 (0.52) | FGFR4CNR2GRM5MEN1KMT2A | |
| SCHEMBL12654181 | 0.85 | MPL (0.42) | FGFR4CNR2GRM5CNR1ALDH1A1 | |
| SCHEMBL12654438 | 0.85 | POLB (0.42) | FGFR4CNR2GRM5MAPTMEN1 | |
| SCHEMBL12654123 | 0.85 | GPR142 (0.39) | CNR2MAPTCNR1 | |
| SCHEMBL12654207 | 0.84 | FGFR4 (0.52) | FGFR4IDO1 | |
| SCHEMBL12654437 | 0.84 | CNR2 (0.41) | CNR2SMN1; SMN2CNR1ALDH1A1 | |
| SCHEMBL12654651 | 0.84 | FGFR4 (0.41) | FGFR4CNR2KMT2ANPC1RAB9A | |
| SCHEMBL16775936 | 0.83 | FGFR4 (0.43) | FGFR4CNR2GRM5MAPTMEN1 | |
| SCHEMBL12654219 | 0.83 | FGFR4 (0.43) | FGFR4CNR2GRM5CNR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |