Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 18/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654661 | 0.88 | FGFR4 (0.55) | FGFR4 | |
| SCHEMBL12653785 | 0.86 | FGFR4 (0.59) | FGFR4 | |
| SCHEMBL12654219 | 0.86 | FGFR4 (0.43) | FGFR4IDO1 | |
| SCHEMBL17655398 | 0.85 | FGFR4 (0.47) | FGFR4 | |
| SCHEMBL16775936 | 0.84 | FGFR4 (0.43) | FGFR4IDO1 | |
| SCHEMBL12654650 | 0.84 | FGFR4 (0.45) | FGFR4IDO1 | |
| SCHEMBL12654216 | 0.84 | FGFR4 (0.62) | FGFR4 | |
| SCHEMBL17655345 | 0.83 | GRM5 (0.48) | FGFR4 | |
| SCHEMBL12654432 | 0.82 | FGFR4 (0.43) | FGFR4IDO1 | |
| SCHEMBL12654192 | 0.82 | FGFR4 (0.40) | FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |