Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 3/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 4/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16917410 | 0.98 | TP53 (0.41) | TP53PLA2G2CADH1BADH1CADH1A | |
| SCHEMBL24665644 | 0.98 | TP53 (0.41) | TP53PLA2G2CADH1BADH1CADH1A | |
| SCHEMBL15632534 | 0.98 | TP53 (0.41) | TP53DNM1PLA2G2CADH1BADH1C | |
| SCHEMBL24667475 | 0.98 | TP53 (0.41) | TP53PLA2G2CADH1BADH1CADH1A | |
| SCHEMBL11335725 | 0.96 | TP53 (0.42) | TP53PLA2G2CADH1BADH1CADH1A | |
| SCHEMBL12656354 | 0.94 | TP53 (0.38) | TP53PLA2G2CADH1BADH1CADH1A | |
| SCHEMBL14473485 | 0.90 | TP53 (0.38) | TP53PLA2G2CADH1BADH1CADH1A | |
| SCHEMBL22299735 | 0.89 | CA2 (0.33) | TP53DNM1PLA2G2CCA2FDPS | |
| SCHEMBL14204950 | 0.80 | SMN1; SMN2 (0.34) | CA2 | |
| SCHEMBL24665666 | 0.79 | ADH1B (0.52) | TP53ADH1BADH1CADH1AADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316829-A1 | Heterocyclic derivatives as modulators of ion channels | Vertex Pharmaceuticals Incorporated (US) | 2011-05-04 | — | — | EP | disclosed |