Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 9/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.38 |
| ▸ | PRKACA | P17612 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | CDK8 | P49336 | 4/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.38 |
| ▸ | CLK2 | P49760 | 4/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | MELK | Q14680 | 3/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.38 |
| ▸ | CDK7 | P50613 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12658026 | 0.78 | NR4A2 (0.48) | KDM4E | |
| SCHEMBL12658121 | 0.78 | IGF1R (0.37) | FLT1KDRKDM4E | |
| SCHEMBL12658267 | 0.76 | MAP2K1 (0.48) | MAP2K1CAMKK2BRD4CDC7CLK4 | |
| SCHEMBL12658207 | 0.72 | NR4A2 (0.45) | KDM4E | |
| SCHEMBL12658224 | 0.70 | PIM1 (0.55) | MAP2K1CAMKK2BRD4CDC7CLK4 | |
| SCHEMBL12658125 | 0.68 | NR4A2 (0.50) | MAP2K1CAMKK2BRD4CDC7CLK4 | |
| SCHEMBL12658128 | 0.68 | — | — | |
| SCHEMBL20846298 | 0.67 | MAP2K1 (0.70) | MAP2K1CAMKK2BRD4CDC7CLK4 | |
| SCHEMBL30610297 | 0.67 | MAP2K1 (0.70) | MAP2K1CAMKK2BRD4CDC7CLK4 | |
| SCHEMBL12658127 | 0.66 | NR4A2 (0.57) | GSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711486-B1 | BIS-INDOLE PYRROLES USEFUL AS ANTIMICROBIAL AGENTS | NEREUS PHARMACEUTICALS INC (US) | 2011-05-11 | — | — | EP | disclosed |