Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12658026 | 0.89 | NR4A2 (0.48) | KDM4ENR4A2KMT2AALDH1A1MTNR1A | |
| SCHEMBL14215657 | 0.84 | KDM4E (0.46) | IGF1RPDGFRBKITPDGFRAFLT1 | |
| SCHEMBL12658207 | 0.84 | NR4A2 (0.45) | KDM4ENR4A2KMT2AALDH1A1MTNR1A | |
| SCHEMBL14188730 | 0.81 | NR4A2 (0.54) | IGF1RPDGFRBKITPDGFRAFLT1 | |
| SCHEMBL12658114 | 0.80 | SPR (0.42) | IGF1RPDGFRBKITPDGFRAFLT1 | |
| SCHEMBL14188731 | 0.78 | SPR (0.41) | IGF1RPDGFRBKITPDGFRAFLT1 | |
| SCHEMBL12658016 | 0.78 | SLC6A4 (0.37) | IGF1RPDGFRBKITPDGFRAFLT1 | |
| SCHEMBL12658265 | 0.78 | MAP2K1 (0.46) | FLT1KDRKDM4E | |
| SCHEMBL12658136 | 0.77 | F7 (0.45) | NR4A2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL12658115 | 0.77 | NR4A2 (0.45) | KDM4ENR4A2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711486-B1 | BIS-INDOLE PYRROLES USEFUL AS ANTIMICROBIAL AGENTS | NEREUS PHARMACEUTICALS INC (US) | 2011-05-11 | — | — | EP | disclosed |