Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 4/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.42 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lycogarubin C SCHEMBL12658123 | 0.89 | NR4A2 (0.59) | HTTALPLMAPTNR4A2CREBBP | |
| Lycogarubin C SCHEMBL30742812 | 0.89 | NR4A2 (0.59) | HTTALPLMAPTNR4A2CREBBP | |
| SCHEMBL12658125 | 0.87 | NR4A2 (0.50) | PIM1MAP2K1MAPTNR4A2CAMKK2 | |
| Lycogarubin B SCHEMBL31061720 | 0.80 | HTT (0.50) | HTTALPLMAPTNR4A2CREBBP | |
| SCHEMBL14628298 | 0.80 | MAPT (0.41) | PIM1MAP2K1HTTALPLMAPT | |
| SCHEMBL12658122 | 0.79 | MAPT (0.49) | HTTALPLMAPTNR4A2CREBBP | |
| SCHEMBL12658025 | 0.79 | ALPL (0.49) | HTTALPLMAPTNR4A2CREBBP | |
| Lynamicin E SCHEMBL12658018 | 0.79 | NR4A2 (0.56) | HTTALPLMAPTNR4A2CREBBP | |
| SCHEMBL12658127 | 0.77 | NR4A2 (0.57) | HTTALPLMAPTNR4A2CREBBP | |
| SCHEMBL12658267 | 0.76 | MAP2K1 (0.48) | PIM1MAP2K1PDPK1TGFBR1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711486-B1 | BIS-INDOLE PYRROLES USEFUL AS ANTIMICROBIAL AGENTS | NEREUS PHARMACEUTICALS INC (US) | 2011-05-11 | — | — | EP | disclosed |
| US-7375129-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-7375129-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | PRIVATE LIFE BIOMED AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | PRIVATE LIFE BIOMED AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-7166634-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7166634-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2007-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | IDO1, IDO2, TPH1 | PIM1 363/4885MAP2K1 4190/4885HTT 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.