Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | CRHBP | P24387 | 4/20 | 0.67 |
| ▸ | CRHR2 | Q13324 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.63 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.63 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.63 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12660526 | 0.93 | MEN1 (0.63) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL15096384 | 0.90 | MEN1 (0.57) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL28197565 | 0.86 | HDAC6 (0.64) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL22699960 | 0.86 | MEN1 (0.80) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL12660394 | 0.84 | HDAC6 (0.65) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL28198225 | 0.84 | HDAC6 (0.71) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL22699961 | 0.83 | MEN1 (0.69) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL18648444 | 0.83 | MEN1 (0.64) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL28203805 | 0.83 | HDAC6 (0.70) | MEN1KMT2AL3MBTL1MAPK1MAPT | |
| SCHEMBL12660336 | 0.82 | HDAC6 (0.66) | MEN1KMT2AL3MBTL1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947839-B2 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-7947839-B2 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| WO-2007064345-A9 | HETEROCYCLIC-SUBSTITUTED BIS-1,8 NAPHTHALIMIDE COMPOUNDS, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE | GENENTECH INC (US) | 2007-07-12 | — | — | WO | disclosed |