SCHEMBL12665691

SCHEMBL12665691

Cc1ccc(C)c(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 3/20 0.42
▸ RXRB P28702 3/20 0.42
▸ RAPGEF4 Q8WZA2 1/20 0.41
▸ RXRG P48443 2/20 0.40
▸ KIF11 P52732 2/20 0.40
▸ P2RX1 P51575 1/20 0.39
▸ TMPRSS4 Q9NRS4 1/20 0.39
▸ IKBKB O14920 1/20 0.37
▸ HSP90AA1 P07900 1/20 0.36
▸ GPBAR1 Q8TDU6 2/20 0.36
▸ CTSA P10619 1/20 0.36
▸ NOTUM Q6P988 1/20 0.36
▸ ESRRA P11474 1/20 0.36
▸ AKR1C3 P42330 2/20 0.35
▸ AKR1C2 P52895 2/20 0.35
▸ HTR1A P08908 1/20 0.35
▸ HTR7 P34969 1/20 0.35
▸ PTGES O14684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12629299 0.93 NOTUM (0.41) RXRARXRBRAPGEF4RXRGKIF11
SCHEMBL26375444 0.86 NOTUM (0.46) RXRARXRBRAPGEF4RXRGKIF11
SCHEMBL1133080 0.85 MAPT (0.46) KIF11HSP90AA1NOTUM
SCHEMBL12629284 0.84 SLC1A3 (0.48) RAPGEF4IKBKBAKR1C3AKR1C2HTR1A
SCHEMBL25117795 0.81 NOTUM (0.43) RXRARXRBRAPGEF4RXRGKIF11
SCHEMBL16574102 0.81 GPBAR1 (0.47) RXRARXRBRAPGEF4RXRGP2RX1
SCHEMBL26532922 0.81 RXRB (0.51) RXRARXRBRAPGEF4RXRGKIF11
SCHEMBL26375483 0.79 AKR1C3 (0.43) RXRARXRBRAPGEF4RXRGKIF11
SCHEMBL26017262 0.78 RXRA (0.44) RXRARXRBRAPGEF4RXRGKIF11
SCHEMBL2744691 0.76 RXRB (0.61) RXRARXRBRXRGGPBAR1AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019153135-A1 POLY(ARYL ETHER SULFONE)-ETHER IMIDE COPOLYMER AND PREPARATION METHOD THEREFOR 江门市优巨新材料有限公司 2019-08-15 — — WO disclosed
US-20130224554-A1 SEPARATOR INCLUDING COATING LAYER CONTAINING POLYIMIDE, AND BATTERY INCLUDING THE SAME CHEIL INDUSTRIES, INC. (KR) 2013-08-29 — — US disclosed
EP-2046862-B1 POLY(ARYL ETHER) WITH PENDENT SULFONIC ACID PHENYL GROUPS CA NAT RESEARCH COUNCIL (CA) 2013-02-13 — — EP disclosed
US-7947800-B2 Poly(aryl ether) with pendent sulfonic acid phenyl groups NATIONAL RESEARCH COUNCIL OF CANADA 2011-05-24 — — US disclosed
US-20090203806-A1 POLY(ARYL ETHER) WITH PENDENT SULFONIC ACID PHENYL GROUPS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2009-08-13 — — US disclosed
WO-2008009102-A1 POLY(ARYL ETHER) WITH PENDENT SULFONIC ACID PHENYL GROUPS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2008-01-24 — — WO disclosed
WO-2007128137-A1 POLY(ARYLENE ETHER)S WITH GRAFTING CAPABILITY FROM A BISPHENOL OR BISTHIOPHENOL MONOMER NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2007-11-15 — — WO disclosed
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