Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R46 | P59540 | 12/20 | 1.00 |
| ▸ | TAS2R31 | P59538 | 2/20 | 1.00 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087405 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL14668231 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL13845782 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL14668230 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL13849508 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL15095950 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL309410 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL13849638 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL13845748 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 | |
| SCHEMBL15257507 | 0.81 | TAS2R46 (0.82) | TAS2R46TAS2R31TAS2R10RECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673578-B2 | Methods of identifying antagonists of the hTAS2R46 bitter taste receptor | Deutsches Institut für Ernahrungsforschung Potsdam-Rehbrücke (DE) | 2014-03-18 | — | — | US | disclosed |
| US-8673578-B2 | Methods of identifying antagonists of the hTAS2R46 bitter taste receptor | Deutsches Institut für Ernahrungsforschung Potsdam-Rehbrücke (DE) | 2014-03-18 | — | — | US | disclosed |
| US-20120283324-A1 | ANTAGONISTS AND AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FUR EMAHRUNGSFORSCHUNG POTSDAM-REHBRUCKE (DE) | 2012-11-08 | — | — | US | disclosed |
| US-20120283324-A1 | ANTAGONISTS AND AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FUR EMAHRUNGSFORSCHUNG POTSDAM-REHBRUCKE (DE) | 2012-11-08 | — | — | US | disclosed |
| WO-2011050955-A1 | ANTAGONISTS AND AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POTSDAM-REHBRÜCKE (DE) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283324-A1 | ANTAGONISTS AND AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | TAS2R40, TAS2R50, TAS2R30 | TAS2R46 10/4885TAS2R31 8/4885TAS2R10 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.