TAS2R46

Taste receptor type 2 member 46 · P59540 · TAS2R46 on Sugi Atlas →

4,617 patent compounds predicted against TAS2R46, 2,958 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL309410	0.82	12/20
SCHEMBL2004584	0.82	12/20
SCHEMBL4087405	0.82	12/20
SCHEMBL4410920	0.82	12/20
SCHEMBL1753395	0.62	12/20
SCHEMBL1753501	0.61	12/20
SCHEMBL1536000	0.60	10/20
SCHEMBL1231563	0.52	10/20
SCHEMBL6741385	0.38	10/20
SCHEMBL6745284	0.37	10/20
Desacetoxymatricarin (SCHEMBL3458919)	0.40	9/20
Desacetoxymatricarin (SCHEMBL5004433)	0.40	9/20
11Beta,13-Dihydro-Parthenolide (SCHEMBL6740195)	0.54	8/20
SCHEMBL4992926	0.38	8/20
SCHEMBL4992929	0.38	8/20
SCHEMBL1872742	0.35	8/20
Costunolide (SCHEMBL92714)	1.00	6/20
Costunolide (SCHEMBL4091605)	0.85	6/20
SCHEMBL937997	0.37	6/20
SCHEMBL2220574	0.37	6/20

Clinical trials — most relevant to TAS2R46 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of Efficacy and Safety of Raphamin in the Treatment of Coronavirus Disease 2019 in Outpatients	PHASE3	COMPLETED
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults	nan	COMPLETED
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries	nan	COMPLETED
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste	nan	COMPLETED
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
Flavour Programming: Fruit and Vegetable Palatability	nan	COMPLETED
Allele-specific Expression of a Bitter Taste Receptor	nan	COMPLETED
Study of Taste Deficits	nan	COMPLETED
Astringency and Oral Health	nan	COMPLETED
NUTRACORE, Glycaemic Index and Appetite	nan	COMPLETED
Bitter Taste Receptors in Oropharynx Cancer	nan	UNKNOWN
Genetic Variability in Taste Perception	nan	COMPLETED
Taste Perception and Chronic Disease Risk	nan	COMPLETED
A Study of the Function of Hormones Present In Taste Buds	nan	COMPLETED
Ibuprofen Inhibits Human Sweet Taste	nan	COMPLETED
Sucralose and Lactisole Additions to OGTT in Humans	nan	COMPLETED
CD36 and Human Fat Taste Perception	nan	COMPLETED
The Effect of Lactisole on the Responses to Glucose Solution	nan	UNKNOWN
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Sensory Study: Taste and Tongue Biology	nan	COMPLETED
Impacts of Sugar-Sweetened Beverage on Body Weight	nan	COMPLETED
The Effect of Artificial Sweeteners on Blood Glucose Response	nan	WITHDRAWN
The Obese Taste Bud Study	nan	UNKNOWN
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults	nan	COMPLETED
Sensitive Periods in Early Flavor Learning	nan	COMPLETED
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TAS2R46 binder may also engage these)

Protein	Name	Similarity
Q646E1	—	1.000	Q646E1 →
TAS2R31	Taste receptor type 2 member 31	1.000	landscape →
Q646C0	—	1.000	Q646C0 →
Q645V3	—	1.000	Q645V3 →
Q5Y4Y8	—	1.000	Q5Y4Y8 →
Q645Z6	—	1.000	Q645Z6 →
Q646B9	—	1.000	Q646B9 →
TAS2R45	Taste receptor type 2 member 45	1.000	landscape →
P0DSN6	—	1.000	P0DSN6 →
Q646E0	—	1.000	Q646E0 →
Q646A0	—	1.000	Q646A0 →
Q646A1	—	1.000	Q646A1 →
Q646G1	—	1.000	Q646G1 →
TAS2R30	Taste receptor type 2 member 30	1.000	landscape →
Q645Z7	—	1.000	Q645Z7 →
Q646B4	—	1.000	Q646B4 →
Q646F9	—	0.999	Q646F9 →
Q645Z9	—	0.999	Q645Z9 →
TAS2R43	Taste receptor type 2 member 43	0.999	landscape →
Q5Y500	—	0.999	Q5Y500 →
Q646E2	—	0.999	Q646E2 →
Q645T4	—	0.999	Q645T4 →
Q646C1	—	0.998	Q646C1 →
Q646C2	—	0.998	Q646C2 →
P0DTE0	—	0.998	P0DTE0 →
TAS2R50	Taste receptor type 2 member 50	0.998	landscape →
TAS2R20	Taste receptor type 2 member 20	0.997	landscape →
Q5Y4Z8	—	0.997	Q5Y4Z8 →
Q67ES0	—	0.997	Q67ES0 →
Q646E3	—	0.996	Q646E3 →