Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13225903 | 0.83 | BRAF (0.41) | BRAFRAF1 | |
| SCHEMBL13574109 | 0.82 | BRAF (0.48) | BRAFRAF1 | |
| SCHEMBL13225905 | 0.82 | BRAF (0.41) | BRAFRAF1 | |
| SCHEMBL12671175 | 0.81 | BRAF (0.49) | BRAFRAF1 | |
| SCHEMBL12671534 | 0.75 | CDK4 (0.39) | BRAF | |
| SCHEMBL1847410 | 0.70 | BRAF (0.51) | BRAF | |
| SCHEMBL13225923 | 0.68 | MAP4K1 (0.41) | — | |
| SCHEMBL12671538 | 0.67 | BRAF (0.50) | BRAF | |
| SCHEMBL12671465 | 0.66 | ALK (0.41) | BRAF | |
| SCHEMBL13225922 | 0.66 | MAP4K1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079988-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |
| WO-2008079988-A2 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2008-07-03 | — | — | WO | disclosed |