Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12671175 | 0.85 | BRAF (0.49) | BRAFRAF1 | |
| SCHEMBL12671174 | 0.82 | BRAF (0.45) | BRAFRAF1 | |
| SCHEMBL12671537 | 0.81 | BRAF (0.44) | BRAFRAF1 | |
| SCHEMBL13252021 | 0.72 | CDK4 (0.42) | BRAF | |
| SCHEMBL17529301 | 0.69 | BRAF (0.49) | BRAF | |
| SCHEMBL13363057 | 0.67 | BRAF (0.48) | BRAFRAF1 | |
| SCHEMBL13252103 | 0.66 | BRAF (0.46) | BRAF | |
| SCHEMBL25880788 | 0.66 | MAP3K5 (0.61) | BRAFRAF1 | |
| SCHEMBL30512106 | 0.66 | MAP3K5 (0.61) | BRAFRAF1 | |
| SCHEMBL13225904 | 0.65 | BRAF (0.45) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |