Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574109 | 0.85 | BRAF (0.48) | BRAFRAF1 | |
| SCHEMBL17529301 | 0.84 | BRAF (0.49) | BRAFPTK2 | |
| SCHEMBL12671174 | 0.81 | BRAF (0.45) | BRAFRAF1 | |
| SCHEMBL13225904 | 0.80 | BRAF (0.45) | BRAFPTK2RAF1 | |
| SCHEMBL12120858 | 0.79 | BRAF (0.53) | BRAF | |
| SCHEMBL3040980 | 0.77 | BRAF (0.69) | BRAFRAF1 | |
| SCHEMBL20711031 | 0.76 | CDK1 (0.44) | BRAF | |
| SCHEMBL5495505 | 0.75 | ADRB2 (0.58) | BRAFPTK2MAPT | |
| SCHEMBL3426624 | 0.74 | BRAF (0.60) | BRAFMAPT | |
| SCHEMBL13362999 | 0.73 | BRAF (0.52) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079988-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |
| WO-2009153313-A1 | 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2009-12-23 | — | — | WO | disclosed |
| WO-2008079988-A2 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2008-07-03 | — | — | WO | disclosed |