Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18037721 | 1.00 | MAPT (0.42) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL17231868 | 1.00 | MAPT (0.42) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL16693695 | 0.94 | MAPT (0.39) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL14616553 | 0.93 | MAPT (0.44) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL21098757 | 0.88 | LMNA (0.42) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL21052222 | 0.88 | LMNA (0.42) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL22787137 | 0.88 | LMNA (0.34) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL22787187 | 0.88 | KMT2A (0.35) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL14616552 | 0.88 | MAPT (0.39) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL15290542 | 0.87 | MAPT (0.39) | MAPTALDH1A1SMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330244-A1 | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITOR-CONJUGATES AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2023-10-19 | — | — | US | disclosed |
| US-20230330244-A1 | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITOR-CONJUGATES AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2023-10-19 | — | — | US | disclosed |
| US-11576981-B2 | Acyl hydrazone linkers, methods and uses thereof | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2023-02-14 | — | — | US | disclosed |
| US-20200397916-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2020-12-24 | — | — | US | disclosed |
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | PFIZER INC. (US) | 2019-12-17 | — | — | US | disclosed |
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | PFIZER INC. (US) | 2019-12-17 | — | — | US | disclosed |
| US-10343989-B2 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH LLC (US) | 2019-07-09 | — | — | US | disclosed |
| WO-2019109188-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-06-13 | — | — | WO | disclosed |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2018-05-17 | — | — | US | disclosed |
| US-8546549-B2 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH LLC (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130018179-A1 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | WYETH LLC (US) | 2013-01-17 | — | — | US | disclosed |
| US-20130018179-A1 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | WYETH LLC (US) | 2013-01-17 | — | — | US | disclosed |
| US-8273862-B2 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH LLC (US) | 2012-09-25 | — | — | US | disclosed |
| US-8273862-B2 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH LLC (US) | 2012-09-25 | — | — | US | disclosed |
| US-20090312530-A1 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090312530-A1 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
| WO-2007098124-A2 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | WYETH (US) | 2007-08-30 | — | — | WO | disclosed |
| US-20070197455-A1 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070197455-A1 | Processes for the convergent synthesis of calicheamicin derivatives | WYETH (US) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | CALR, CALD1, CYCS | MAPT 4253/4885ALDH1A1 1068/4885SMN1; SMN2 4845/4885 |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | CALR, CALD1, CYCS | MAPT 4253/4885ALDH1A1 1068/4885SMN1; SMN2 4845/4885 |
| US-20230330244-A1 | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITOR-CONJUGATES AND USES THEREOF | NAMPT, NAPRT, NNT | MAPT 200/4885ALDH1A1 610/4885SMN1; SMN2 1372/4885 |
| US-20090312530-A1 | Processes for the convergent synthesis of calicheamicin derivatives | COASY, CALD1, CROCC | MAPT 3669/4885ALDH1A1 3690/4885SMN1; SMN2 4869/4885 |
| US-10343989-B2 | Processes for the convergent synthesis of calicheamicin derivatives | COASY, CALD1, CROCC | MAPT 3669/4885ALDH1A1 3690/4885SMN1; SMN2 4869/4885 |
| US-20130018179-A1 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES | COASY, CALD1, CROCC | MAPT 3669/4885ALDH1A1 3690/4885SMN1; SMN2 4869/4885 |
| US-20070197455-A1 | Processes for the convergent synthesis of calicheamicin derivatives | COASY, CALD1, CROCC | MAPT 3669/4885ALDH1A1 3690/4885SMN1; SMN2 4869/4885 |
| US-20200397916-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | KAT7, AADAC, HDAC7 | MAPT 3413/4885ALDH1A1 194/4885SMN1; SMN2 4352/4885 |
| US-11576981-B2 | Acyl hydrazone linkers, methods and uses thereof | AADAC, HDAC8, KAT8 | MAPT 3082/4885ALDH1A1 169/4885SMN1; SMN2 3796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.