Sugi Predict

Sugi Predict / Compounds / SCHEMBL1267967

SCHEMBL1267967

SCHEMBL1267967

CN(CCOC(=O)c1ccc(C(F)(F)F)cc1)c1c(S(=O)(=O)C(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRP O00591 6/20 0.37
▸ GABRD O14764 6/20 0.37
▸ GABRA1 P14867 6/20 0.37
▸ GABRB1 P18505 6/20 0.37
▸ GABRG2 P18507 6/20 0.37
▸ GABRB3 P28472 6/20 0.37
▸ GABRA5 P31644 6/20 0.37
▸ GABRA3 P34903 6/20 0.37
▸ GABRA2 P47869 6/20 0.37
▸ GABRB2 P47870 6/20 0.37
▸ GABRA4 P48169 6/20 0.37
▸ GABRE P78334 6/20 0.37
▸ GABRA6 Q16445 6/20 0.37
▸ GABRG1 Q8N1C3 6/20 0.37
▸ GABRG3 Q99928 6/20 0.37
▸ GABRQ Q9UN88 6/20 0.37
▸ LMNA P02545 2/20 0.37
▸ NR1I2 O75469 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1266754 0.87 GABRB3 (0.39) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL3425558 0.87 GABRB3 (0.43) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6624975 0.86 GABRB3 (0.42) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL1267183 0.84 GABRB3 (0.43) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL3259440 0.82 GABRB3 (0.43) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6026309 0.82 ALDH1A1 (0.35) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL1266854 0.81 GABRB3 (0.37) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL4415803 0.81 GABRB3 (0.42) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6055588 0.79 GABRB3 (0.48) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6055661 0.79 GABRB3 (0.42) GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1663986-B1 PESTICIDAL 5-SUBSTITUTED-OXYALKYLAMINO-1-ARYLPYRAZOLE DERIVATIVES MERIAL LTD (US) 2013-03-27 — — EP disclosed
US-7879897-B2 Pesticidal 5-substituted-oxyalkylamino-1-arylpyrazole derivatives MERIAL LIMITED (US) 2011-02-01 — — US disclosed
US-20070066596-A1 Pesticidal 5-substituted-oxalkylamino-1-arylpyrazole derivatives BAYER CROPSCIENCE S.A. (FR) 2007-03-22 — — US disclosed
EP-1663986-A1 PESTICIDAL 5-SUBSTITUTED-OXYALKYLAMINO-1-ARYLPYRAZOLE DERIVATIVES Bayer CropScience S.A. (FR) 2006-06-07 — — EP disclosed
WO-2005023776-A1 PESTICIDAL 5-SUBSTITUTED-OXYALKYLAMINO-1-ARYLPYRAZOLE DERIVATIVES BAYER CROPSCIENCE S.A. (FR) 2005-03-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070066596-A1 Pesticidal 5-substituted-oxalkylamino-1-arylpyrazole derivatives OTC, DDT, PTMS GABRP 592/4885GABRD 957/4885GABRA1 1303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.