Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HTR3A | P46098 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253105 | 0.87 | ALDH1A1 (0.62) | SMN1; SMN2LMNAHTR3AKMT2AMEN1 | |
| SCHEMBL4252448 | 0.82 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNAHTR3AKMT2AMEN1 | |
| SCHEMBL11798445 | 0.79 | ALDH1A1 (0.67) | SMN1; SMN2LMNAHTR3AKMT2AMEN1 | |
| SCHEMBL4254796 | 0.75 | ALDH1A1 (0.79) | SMN1; SMN2LMNAHTR3AKMT2AMEN1 | |
| SCHEMBL2117997 | 0.75 | ALDH1A1 (0.62) | SMN1; SMN2HTR3AKMT2AMEN1TP53 | |
| SCHEMBL697589 | 0.75 | PARP1 (0.54) | SMN1; SMN2LMNAHTR3AKMT2AMEN1 | |
| SCHEMBL2115751 | 0.75 | ALDH1A1 (0.78) | SMN1; SMN2LMNAKMT2AMEN1TP53 | |
| SCHEMBL4253425 | 0.74 | KDM4E (0.79) | SMN1; SMN2LMNAHTR3AKMT2AMEN1 | |
| SCHEMBL9743323 | 0.72 | LMNA (0.60) | SMN1; SMN2LMNAKMT2AMEN1TP53 | |
| SCHEMBL11854523 | 0.71 | SMN1; SMN2 (0.78) | SMN1; SMN2LMNAHTR3AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012051036-A1 | QUINAZOLINONE-TYPE COMPOUNDS AS CRTH2 ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-04-19 | — | — | WO | disclosed |