⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24271569 | 0.90 | CARM1 (0.39) | — | |
| SCHEMBL19992869 | 0.83 | — | — | |
| SCHEMBL23984142 | 0.81 | ACHE (0.60) | — | |
| SCHEMBL7853092 | 0.77 | — | — | |
| SCHEMBL13832449 | 0.74 | — | — | |
| SCHEMBL19547052 | 0.74 | HRH4 (0.30) | — | |
| SCHEMBL12819844 | 0.74 | — | — | |
| SCHEMBL7852955 | 0.74 | — | — | |
| SCHEMBL22633323 | 0.73 | — | — | |
| SCHEMBL15805146 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| EP-3929198-A1 | HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2021-12-29 | — | — | EP | disclosed |
| EP-3357916-A1 | BENZAMIDE DERIVATIVE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2018-08-08 | — | — | EP | disclosed |
| EP-3027587-B1 | 1,2-DISUBSTITUTED CYCLOBUTYL COMPOUNDS | ESTEVE LABOR DR (ES) | 2018-07-25 | — | — | EP | disclosed |
| US-9849135-B2 | USP14 inhibitors for treating or preventing viral infections | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-12-26 | — | — | US | disclosed |
| EP-2528911-B1 | COMPOSITIONS AND METHODS FOR ENHANCING PROTEASOME ACTIVITY | HARVARD COLLEGE (US) | 2017-10-25 | — | — | EP | disclosed |
| EP-2927228-B1 | Novel physiologically active substances | EISAI R&D MAN CO LTD (JP) | 2016-09-07 | — | — | EP | disclosed |
| US-20160214989-A1 | Compositions and Methods for Enhancing Proteasome Activity | THE ASSAY DEPOT, INC. | 2016-07-28 | — | — | US | disclosed |
| US-20150335652-A1 | USP14 Inhibitors for Treating or Preventing Viral Infections | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-11-26 | — | — | US | disclosed |
| EP-2927228-A1 | Novel physiologically active substances | Eisai R&D Management Co., Ltd. (JP) | 2015-10-07 | — | — | EP | disclosed |
| CN-1665807-A | Novel physiolgically active substances | MERCIAN CORP (JP) | 2005-09-07 | — | — | CN | disclosed |
| EP-1548121-A1 | NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES | MERCIAN CORPORATION (JP) | 2005-06-29 | — | — | EP | disclosed |
| EP-1541570-A1 | NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE | MERCIAN CORPORATION (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-1508570-A1 | NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES | MERCIAN CORPORATION (JP) | 2005-02-23 | — | — | EP | disclosed |
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |
| EP-0526348-B1 | Indoline derivatives carrying an amide function, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-02-18 | — | — | EP | disclosed |
| WO-1993003013-A1 | INDOLINE DERIVATIVES HAVING AN AMIDE FUNCTION, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELF SANOFI (FR) | 1993-02-18 | — | — | WO | disclosed |
| EP-0526348-A1 | Indoline derivatives carrying an amide function, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1993-02-03 | — | — | EP | disclosed |
| EP-0356333-A1 | 1,3,4-Thiadiazole derivatives, process for their obtention, and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1990-02-28 | — | — | EP | disclosed |