Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | STK17B | O94768 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12537683 | 0.88 | RAF1 (0.44) | MEN1KMT2ACTRCPTGS1PTGS2 | |
| SCHEMBL12537677 | 0.88 | RAF1 (0.44) | MEN1KMT2ACTRCPTGS1PTGS2 | |
| SCHEMBL12537680 | 0.88 | RAF1 (0.44) | MEN1KMT2ACTRCPTGS1PTGS2 | |
| SCHEMBL6015921 | 0.84 | MEN1 (0.62) | MEN1KMT2ACTRCNPC1RAB9A | |
| SCHEMBL6015927 | 0.84 | MEN1 (0.62) | MEN1KMT2ACTRCNPC1RAB9A | |
| SCHEMBL12690199 | 0.82 | STK17B (0.58) | MEN1KMT2ARAB9ASTK17BMAPT | |
| SCHEMBL12537510 | 0.81 | NPC1 (0.39) | MEN1KMT2ACTRCNPC1RAB9A | |
| SCHEMBL12537507 | 0.81 | NPC1 (0.39) | MEN1KMT2ACTRCNPC1RAB9A | |
| SCHEMBL12537509 | 0.81 | NPC1 (0.39) | MEN1KMT2ACTRCNPC1RAB9A | |
| SCHEMBL12537581 | 0.80 | MAP3K11 (0.47) | MEN1KMT2ANPC1RAB9ASTK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567305-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2017-02-14 | — | — | US | disclosed |
| US-9567305-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2017-02-14 | — | — | US | disclosed |
| US-20170008907-A1 | Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors | NATIONAL INSTITUTES OF HEALTH | 2017-01-12 | — | — | US | disclosed |
| US-20170008907-A1 | Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors | NATIONAL INSTITUTES OF HEALTH | 2017-01-12 | — | — | US | disclosed |
| US-9493452-B2 | Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors | SOUTHERN METHODIST UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-9493452-B2 | Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors | SOUTHERN METHODIST UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-8669363-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-03-11 | — | — | US | disclosed |
| US-8669363-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120245347-A1 | Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120245347-A1 | Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245347-A1 | Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors | LRRK2, BRAF, RAF1 | MEN1 2436/4885KMT2A 1874/4885CTRC 4050/4885 |
| US-20170008907-A1 | Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors | LRRK2, BRAF, RAF1 | MEN1 2436/4885KMT2A 1874/4885CTRC 4050/4885 |
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | MEN1 1575/4885KMT2A 2666/4885CTRC 3162/4885 |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | MEN1 1575/4885KMT2A 2666/4885CTRC 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.