Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 6/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | MIF | P14174 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269775 | 0.89 | PDE4B (0.48) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL13042835 | 0.85 | PDE4B (0.55) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL3195011 | 0.84 | PDE4B (0.69) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL1270326 | 0.83 | PDE4B (0.44) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL13044531 | 0.81 | PDE4B (0.52) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL3205166 | 0.80 | PDE4B (0.59) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL3197388 | 0.80 | PDE4B (0.55) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL13044530 | 0.79 | PDE4B (0.59) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL5430843 | 0.79 | MAPK9 (0.59) | PDE4BMAPK9MAPK10PDE10APDE5A | |
| SCHEMBL3197426 | 0.78 | PDE4B (0.48) | PDE4BMAPK9MAPK10PDE10APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039873-A1 | SUBSTITUTED PYRAZOLO[1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY | MEDICINOVA, INC. | 2011-02-17 | — | — | US | disclosed |
| US-20110039873-A1 | SUBSTITUTED PYRAZOLO[1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY | MEDICINOVA, INC. | 2011-02-17 | — | — | US | disclosed |
| US-20110039873-A1 | SUBSTITUTED PYRAZOLO[1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY | MEDICINOVA, INC. | 2011-02-17 | — | — | US | disclosed |
| WO-2010144416-A1 | SUBSTITUTED PYRAZOLO [1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY | GAETA FEDERICO C A (US) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039873-A1 | SUBSTITUTED PYRAZOLO[1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY | PARK7, MAPKAPK5, MAPK1 | PDE4B 43/4885MAPK9 65/4885MAPK10 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.