Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.79 |
| ▸ | NPC1 | O15118 | 10/20 | 0.79 |
| ▸ | MAPT | P10636 | 6/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.79 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.79 |
| ▸ | RELA | Q04206 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | AR | P10275 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12692378 | 0.88 | NPC1 (1.00) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL12288886 | 0.80 | SMN1; SMN2 (0.80) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL2553839 | 0.80 | SMN1; SMN2 (1.00) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL29546111 | 0.79 | RAB9A (0.54) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL3004754 | 0.75 | SMN1; SMN2 (1.00) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL17266249 | 0.75 | SMN1; SMN2 (1.00) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL18674671 | 0.73 | AR (0.97) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL5328162 | 0.73 | NPC1 (1.00) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL19051409 | 0.72 | AR (0.62) | RAB9ASMN1; SMN2NPC1MAPTKDM4E | |
| SCHEMBL12647915 | 0.72 | NPC1 (0.69) | RAB9ASMN1; SMN2NPC1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160022691-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH | SOUTHERN RES INST (US) | 2016-01-28 | — | — | US | disclosed |
| US-20120245166-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH | SOUTHERN RESEARCH INSTITUTE (US) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022691-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH | NFKBIA, NFRKB, TFEB | RAB9A 2424/4885SMN1; SMN2 33/4885NPC1 489/4885 |
| US-20120245166-A1 | TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH | NFKBIA, NFRKB, TFEB | RAB9A 2402/4885SMN1; SMN2 29/4885NPC1 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.