Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Moxonidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH known ✓ | Q9Y2I1 | 3/20 | 0.77 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.77 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.77 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | HTR1A | P08908 | 2/20 | 0.77 |
| ▸ | HRH2 | P25021 | 2/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 4/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | CFB | P00751 | 5/20 | 0.46 |
| ▸ | HTR1D | P28221 | 5/20 | 0.44 |
| ▸ | HTR1B | P28222 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Moxonidine SCHEMBL49143 | 0.88 | ADRA2C (1.00) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Moxonidine SCHEMBL29363838 | 0.88 | ADRA2C (1.00) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Moxonidine SCHEMBL8390103 | 0.88 | ADRA2C (1.00) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Moxonidine SCHEMBL1321306 | 0.86 | BLM (1.00) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Moxonidine SCHEMBL30484346 | 0.85 | BLM (0.97) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Moxonidine SCHEMBL1230620 | 0.85 | BLM (0.97) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Tiamenidine SCHEMBL112844 | 0.84 | HTR1D (0.60) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Tiamenidine SCHEMBL1650568 | 0.83 | HTR1D (0.59) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Tiamenidine SCHEMBL122565 | 0.83 | HTR1D (0.59) | ADRA2CADRA2AADRA2BADRA1ALMNA | |
| Moxonidine SCHEMBL8007695 | 0.81 | ADRA2C (0.86) | ADRA2CADRA2AADRA2BADRA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879802-B2 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders | SYNERGY PHARMACEUTICALS INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20090048175-A1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS | SYNERGY PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | US | disclosed |