Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.60 |
| ▸ | HTR1B | P28222 | 4/20 | 0.54 |
| ▸ | CFB | P00751 | 5/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.53 |
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.53 |
| ▸ | HRH2 | P25021 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiamenidine SCHEMBL122565 | 0.98 | HTR1D (0.59) | HTR1DHTR1BCFBADRA2CADRA2A | |
| Tiamenidine SCHEMBL1650568 | 0.98 | HTR1D (0.59) | HTR1DHTR1BCFBADRA2CADRA2A | |
| Moxonidine SCHEMBL1269296 | 0.84 | ADRA2C (0.77) | HTR1DHTR1BCFBADRA2CADRA2A | |
| Tizanidine SCHEMBL8312917 | 0.83 | ADRA2A (0.77) | HTR1DHTR1BCFBADRA2CADRA2A | |
| SCHEMBL11176814 | 0.79 | ADRA2A (0.79) | HTR1DHTR1BCFBADRA2CADRA2A | |
| SCHEMBL4760243 | 0.76 | HTR1D (1.00) | HTR1DHTR1BCFBADRA2CADRA2A | |
| Hydrochloric Acid SCHEMBL29384552 | 0.74 | HTR1D (0.97) | HTR1DHTR1BCFBADRA2CADRA2A | |
| SCHEMBL11187565 | 0.72 | HTR1D (0.76) | HTR1DHTR1BCFBADRA2CADRA2A | |
| SCHEMBL14976356 | 0.72 | CFB (0.67) | HTR1DHTR1BCFBADRA2CADRA2A | |
| SCHEMBL2333058 | 0.71 | ADRA2C (0.76) | HTR1DHTR1BCFBADRA2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2348 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-12472158-B2 | Methods of treating trigeminal nerve pain | VANDERBILT UNIVERSITY (US) | 2025-11-18 | — | — | US | claimed |
| WO-2025080559-A1 | METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE | ENALARE THERAPEUTICS INC. (US) | 2025-04-17 | — | — | WO | claimed |
| US-20250114370-A1 | METHODS AND COMPOSITIONS FOR TREATING DRUG OVERDOSE | ENALARE THERAPEUTICS INC (US) | 2025-04-10 | — | — | US | claimed |
| EP-3359134-B1 | COMPOSITIONS AND COMPOSITIONS FOR USE IN ON-DEMAND HIGH-EFFICIENCY TRIGGERABLE ANESTHESIA | CHILDRENS MEDICAL CT CORP (US) | 2025-04-09 | — | — | EP | claimed |
| WO-2024249843-A2 | GUANFACINE FOR FATIGUE DISORDERS | VANDERBILT UNIVERSITY (US) | 2024-12-05 | — | — | WO | claimed |
| WO-2024226608-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | AGLAEAPHARMA INC. (US) | 2024-10-31 | — | — | WO | claimed |
| US-20240139181-A1 | METHODS FOR INDUCING PUPIL DILATION | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2024-05-02 | — | — | US | claimed |
| US-11738022-B2 | Methods for inducing pupil dilation | THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-08-29 | — | — | US | claimed |
| US-11344498-B2 | Compositions and methods for on-demand high-efficiency triggerable anesthesia | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2022-05-31 | — | — | US | claimed |
| EP-0719139-A1 | USE OF CENTRALLY ACTIVE ALPHAAGONISTS FOR INHIBING POSTRAUMATIC METABOLIC STRESS | Dr. Karl Thomae GmbH (DE) | 1996-07-03 | — | — | EP | claimed |
| WO-1996018605-A1 | ACYLOXYISOPROPYL CARBAMATES AS PRODRUGS FOR AMINE DRUGS | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | claimed |
| WO-1995003798-A2 | USE OF CENTRALLY EFFECTIVE α-2 AGONISTS FOR INHIBITING POSTAGGRESSION METABOLISM | BOEHRINGER INGELHEIM INT (DE) | 1995-02-09 | — | — | WO | claimed |
| EP-0573581-A4 | COMPOSITIONS AND METHODS OF TREATMENT OF SYMPATHETICALLY MAINTAINED PAIN | ARC 1 INC (US) | 1994-06-29 | — | — | EP | claimed |
| EP-0573581-A1 | COMPOSITIONS AND METHODS OF TREATMENT OF SYMPATHETICALLY MAINTAINED PAIN | ARC 1, Inc. (US) | 1993-12-15 | — | — | EP | claimed |
| WO-1992014453-A1 | COMPOSITIONS AND METHODS OF TREATMENT OF SYMPATHETICALLY MAINTAINED PAIN | ARC 1, INC. (US) | 1992-09-03 | — | — | WO | claimed |
| EP-0170193-B1 | FEEDSTUFF ADDITIVE FOR THE GROWTH PROMOTING OF AGRICULTURAL USEFUL ANIMALS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1991-12-27 | — | — | EP | claimed |
| US-4931281-A | Laminar structure for administering a chemical at a controlled release rate | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0243891-A2 | A laminar structure for administering a chemical at a controlled release rate | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-11-04 | — | — | EP | claimed |
| EP-0170193-A2 | Feedstuff additive for the growth promoting of agricultural useful animals | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1986-02-05 | — | — | EP | claimed |