Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2449812 | 0.95 | SMN1; SMN2 (0.53) | CNR2SMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL6770688 | 0.94 | LMNA (0.54) | CNR2SMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL13607844 | 0.92 | HTT (0.53) | CNR2SMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL28919413 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTALDH1A1LMNAMAPT | |
| SCHEMBL9774307 | 0.91 | KMT2A (0.51) | CNR2ALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL9774386 | 0.91 | ALDH1A1 (0.56) | SMN1; SMN2HTTALDH1A1LMNAMAPT | |
| SCHEMBL6043205 | 0.88 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTALDH1A1LMNAMAPT | |
| SCHEMBL17980842 | 0.87 | TSHR (0.53) | ALDH1A1L3MBTL1KDM4EMEN1RECQL | |
| SCHEMBL7827302 | 0.87 | SMN1; SMN2 (0.53) | CNR2SMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL8080660 | 0.86 | MEN1 (0.57) | CNR2LMNAMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-08-06 | — | — | US | disclosed |
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2012106534-A2 | HIV INTEGRASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | CNR2 4787/4885SMN1; SMN2 4523/4885HTT 4595/4885 |
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | CNR2 4787/4885SMN1; SMN2 4523/4885HTT 4595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.